Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis

Table 6 Diagnostic performance of serum M30-antigen and M65-antigen levels in discriminating NAFLD patients with severe fibrosis from subjects with early fibrosis

	Cut-off value1(IU/L)	Sensitivity(95% CI) (%)	Specificity(95% CI) (%)	Positive predictivevalue (%)	Negative predictivevalue (%)	Negativelikelihood ratio	Area under thecurve (95% CI)
M30-antigen	121.6	64.7 (38.4-85.7)	77.3 (65.3-86.7)	42.30	89.50	0.46	0.733 (0.624-0.824)
M65-antigen	243.82	70.6 (44.1-89.6)	71.2 (58.7-81.7)	38.70	90.40	0.41	0.742 (0.635-0.832)

¹Cut-off value corresponding to the highest accuracy value (minimal false negative and false positive results).