Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis

Table 4 Concentrations of serum M30-antigen and M65-antigen in the study groups

Biomarker	Definitive NASH(n = 45)	Borderline NASH(n = 24)	Simple steatosis(n = 9)	Normal tissue(n = 5)	Healthy volunteers(n = 49)	No-NASH(n = 38)	1P
M30-antigen (IU/L)	200.4 ± 183.1	69.8 ± 37.1	60.1 ± 36.8	81.0 ± 17.5	43.3 ± 45.9	69.0 ± 34.9	< 0.001
2P	Reference category	< 0.001	< 0.01	NS	< 0.001	< 0.001
M65-antigen (IU/L)	362.8 ± 178.7	210.6 ± 59.6	215.3 ± 78.2	207.0 ± 47.4	150.9 ± 44.1	211.2 ± 61.5	< 0.001
2P	Reference category	< 0.001	< 0.01	< 0.05	< 0.001	< 0.001

¹P value calculated using Kruskal-Wallis test.

²Comparisons between definitive NASH patients and other patient groups were performed by Mann-Whitney U Test.