Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis

Table 2 Histological findings in 83 patients with suspected NAFLD

Variable	Definition	Score	Entire cohort(n = 83) (%)	Definitive NASH(n = 45) (%)	Borderline NASH(n = 24) (%)	Simple steatosis(n = 9) (%)	Normal tissue(n = 5) (%)
Steatosis	< 5%	0	8.40	0	8.30	0	100
	5%-33%	1	39.80	13.30	75.00	100	0
	> 33%-66%	2	30.10	46.70	16.70	0	0
	> 66%	3	21.70	40.00	0	0	0
Lobular inflammation (foci per 200 × field)	No foci	0	15.70	0	0	88.90	100
	< 2 foci	1	26.50	8.90	70.80	11.10	0
	2-4 foci	2	43.40	64.40	29.20	0	0
	> 4 foci	3	14.50	26.70	0	0	0
Ballooning	None	0	12	0	0	55.60	100
	Few balloon cells	1	24.10	6.70	70.90	44.40	0
	Many cells/prominent ballooning	2	63.90	93.30	29.10	0	0
Fibrosis stage	None	0	54.20	33.30	66.70	100	100
	Mild, zone 3, perisinusoidal	1A	8.40	11.10	8.30	0	0
	Moderate, zone 3, perisinusoidal	1B	3.60	6.70	0	0	0
	Portal/periportal	1C	13.30	15.60	16.60	0	0
	Perisinusoidal and portal/periportal	2	13.30	22.20	4.20	0	0
	Bridging fibrosis	3	7.20	11.10	4.20	0	0
	Cirrhosis	4	0	0	0	0	0