Alterations of glutathione S-transferase and matrix metalloproteinase-9 expressions are early events in esophageal carcinogenesis

Figure 2 Expression of MMP-9 in different esophageal tissues. Strong positive immunostaining of MMP-9 in (A) Barrett’s metaplasia (400 ×), (B) dysplasia (400 ×) and (C) adenocarcinoma (200 ×) of the esophagus. Cytoplasm of the metaplastic and dysplastic cells and cytoplasmic membranes of the esophageal adenocarcinoma cells were stained brown. Barrett’s metaplasia with concomitant dysplasia and adenocarcinoma show the most intensive expression of MMP-9.