Survey of molecular profiling during human colon cancer development and progression by immunohistochemical staining on tissue microarray

Table 6 PTEN and p-Akt1 status in relation to clinicopathological data

Clinicopathologicalparameters		Total	PTEN				P	p-Akt1				P
			-	+	++	+++		-	+	++	+++
Age	< 58	39	3	2	20	14	0.8602	10	0	16	13	0.4081
	≥ 58	46	2	2	22	20		9	3	19	15
Gender	Male	48	4	4	24	16	0.1672	14	0	19	15	0.0961
	Female	37	1	0	18	18		5	3	16	13
Histological grade	Low	24	4	2	14	4		11	3	6	4
	Moderate	50	1	2	24	23	0.0292	8	0	26	16	0.0002
	High	11	0	0	4	7		0	0	3	8
Lymph node metastasis	Negative	53	3	2	22	26	0.1322	7	1	26	19	0.0321
	Positive	32	2	2	20	8		12	2	9	9
Distant metastasis	Negative	71	2	3	37	29	0.0602	13	3	31	24	0.2752
	Positive	14	3	1	5	5		6	0	4	4
Dukes stage	A	15	0	1	7	7		1	0	6	8
	B	33	1	1	15	16	0.2812	4	1	17	11	0.1062
	C	23	1	1	15	6		8	2	8	5
	D	14	3	1	5	5		6	0	4	4

¹ Chi-square test;

² Fisher’s exact test.