Survey of molecular profiling during human colon cancer development and progression by immunohistochemical staining on tissue microarray

Table 4 Cox-2 and nm23-h1 status in relation to clinicopathological data

Groups		n	Cox-2				P	nm23-h1				P
			-	+	++	+++		-	+	++	+++
Age (yr)	< 58	39	3	1	17	18	0.239	4	3	21	10	0.272
	≥ 58	46	1	3	13	29		1	4	22	19
Gender	Male	48	1	2	17	28	0.628	5	5	24	14	0.157
	Female	37	3	2	13	19		0	2	19	15
Histological grade	Low	24	3	3	12	6		3	6	13	2
	Moderate	50	1	1	14	33	0.008	2	0	23	24	0.000
	High	11	0	0	4	7		0	1	7	3
Lymph node metastasis	Negative	53	1	2	17	33	0.223	2	3	29	18	0.434
	Positive	32	3	2	13	14		3	4	14	11
Distant metastasis	Negative	71	1	3	27	40	0.026	3	3	39	26	0.008
	Positive	14	3	1	3	7		2	4	4	3
Dukes stage	A	15	0	1	3	11		1	1	11	2
	B	33	0	0	12	21	0.016	0	1	16	16	0.014
	C	23	1	2	12	8		2	1	12	8
	D	14	3	1	3	7		2	4	4	3

Fisher’s exact test.