Survey of molecular profiling during human colon cancer development and progression by immunohistochemical staining on tissue microarray

Table 2 p53, p21, cyclin D1, bcl-2 and bax status in relation to clinicopathological parameters

Clinicopathalogicalparameters		Total	p53				P	p21				P	cyclinD1				P	bcl-2				P	bax				P
			-	+	++	+++		-	1+	2+	3+		-	1+	2+	3+		-	+	++	+++		-	+	++	+++
Age	< 58	39	17	5	8	9	0.3011	10	4	13	12	0.9661	8	6	13	12	0.7521	3	1	21	13	0.6542	11	3	17	8	0.7721
	≥ 58	46	22	1	11	12		9	5	15	14		9	10	17	10		2	0	25	19		10	6	22	8
Gender	Male	48	24	2	10	12	0.6081	12	1	17	16	0.0401	11	9	16	12	0.8911	5	1	26	16	0.1392	14	6	20	8	0.5791
	Female	37	15	4	9	9		7	8	11	10		6	7	14	10		0	0	20	16		7	3	19	8
Histological grade	Low	24	18	0	3	3		10	4	3	6		9	4	8	3		3	1	16	4		11	3	9	1
	Moderate	50	17	3	13	17	0.0052	6	3	21	18	0.0132	5	9	20	16	0.0822	2	0	24	23	0.0752	8	6	25	11	0.0442
	High	11	4	3	3	1		3	2	4	2		3	3	2	3		0	0	6	5		2	0	5	4
Lymph node metastasis	Negative	53	19	4	16	14	0.0671	9	4	19	19	0.1991	11	11	20	11	0.5751	2	0	29	21	0.4072	10	6	26	11	0.4571
	Positive	32	20	2	3	7		10	5	9	7		6	5	10	11		3	1	17	11		11	3	13	5
Distant metastasis	Negative	71	30	6	18	17	0.2922	14	8	23	23	0.6442	12	16	24	19	0.1002	3	0	39	29	0.0522	17	7	32	15	0.6942
	Positive	14	9	0	1	4		5	1	5	3		5	0	6	3		2	1	8	3		4	2	7	1
Dukes stage	A	15	5	2	6	2		3	2	5	5		2	7	4	2		0	0	9	6		2	2	8	3
	B	33	10	2	9	12	0.0612	3	2	13	13	0.2862	7	4	15	7	0.0382	1	0	18	14	0.4872	6	3	16	8	0.7162
	C	23	15	2	3	3		8	4	5	5		3	5	5	10		2	0	12	9		9	2	8	4
	D	14	9	0	1	4		5	1	5	3		5	0	6	3		2	1	8	3		4	2	7	1

¹ Chi-square test;

² Fisher’s exact test.