Survey of molecular profiling during human colon cancer development and progression by immunohistochemical staining on tissue microarray

Table 1 Comparison of IHC results (p53, p21, cyclin D1, bcl-2 and bax) among varying tissues

Groups	n	p53				P	p21				P	Cyclin D1				P	bcl-2				P	bax				P
		-	+	++	+++		-	+	++	+++		-	+	++	+++		-	+	++	+++		-	+	++	+++
Cancer	85	39	6	19	21		19	9	28	26		17	16	30	22		5	1	46	32		21	9	39	16
Adenomas	18	15	2	1	0	0.0032	8	5	4	1	0.0001	3	7	8	0	0.0001	1	1	7	8	0.0012	0	0	9	9	0.0001
Benign tissue	9	9	0	0	0		9	0	0	0		8	1	0	0		2	3	3	0		0	1	1	7
Total	112	63	8	20	21		36	14	32	27		28	24	38	22		8	5	56	40		21	10	49	32

¹Chi-square test;

²Fisher’s exact test.