Effect of arsenic trioxide on vascular endothelial cell proliferation and expression of vascular endothelial growth factor receptors Flt-1 and KDR in gastric cancer in nude mice

Figure 4 Effective inhibition of expression of KDR (VEGFR-2) in the xenograft tumors by treatment with arsenic trioxide. KDR expression was determined by Immunofluorescence staining and laser confocal microscopy. Original magnification × 400. A: Control group; B: 2.5 mg/kg group; C: 5 mg/kg group; D: Quantitative analysis of fluorescence intensity in the three groups of tumors was measured using the Leica Confocal analysis system. Data are given as mean and SE.