JAK-STAT pathway in carcinogenesis: Is it relevant to cholangiocarcinoma progression

doi:10.3748/wjg.v13.i48.6478

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Dec 28, 2007 (publication date) through Dec 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2007; 13(48): 6478-6491
Published online Dec 28, 2007. doi: 10.3748/wjg.v13.i48.6478

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Figure 1 Schematic representation of JAK-STAT signaling induced by hormones, cytokines, and growth factors. RTK: Receptors tyrosine kinases; JAK: Jannus kinase; STA: Signal transducer and activator of transcription; SOCS: Suppressor of cytokine signaling; CIS: Cytokine induced suppressor; PIAS: Protein inhibitors of activated STATs. Solid arrows - phosphorylation; Dashed arrows - nuclear translocation; Blunt arrows - inhibition; Red circles - phosphorylated tyrosines.

Citation: Smirnova OV, Ostroukhova TY, Bogorad RL. JAK-STAT pathway in carcinogenesis: Is it relevant to cholangiocarcinoma progression. World J Gastroenterol 2007; 13(48): 6478-6491
URL: https://www.wjgnet.com/1007-9327/full/v13/i48/6478.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i48.6478