Acanthus ilicifolius plant extract prevents DNA alterations in a transplantable Ehrlich ascites carcinoma-bearing murine model

Table 6 Effect of ALE on the generation of average number of single-strand breaks (SSBs)/DNA fragment in murine liver 24 h and 5 d post-EAC transplantation

Time followingEAC inoculation	Group	DS-DNA(%)	No. of SSBs/DNA fragment	Inhibition(%)
24 h	Normal control	94.75	0.07 ± 0.01	----
	EAC control	79.57	1.28 ± 0.22b	----
	ALE control	94.87	0.07 ± 0.02	----
	EAC + ALE	88.23	1.14 ± 0.15	----
5 d	Normal control	95.12	0.08 ± 0.03	----
	EAC control	17.21	3.14 ± 0.31b	----
	ALE control	94.93	0.07 ± 0.3	----
	EAC + ALE	55.83	1.93 ± 0.23d	38.53

ALE: Aqueous leaf extract of A. ilicifolius; EAC: Ehrlich ascites carcinoma. Values represent mean ± SE (n = 10).

^bP < 0.001 vs Normal control;

^dP < 0.01 vs EAC control.