JAK-STAT pathway in carcinogenesis: Is it relevant to cholangiocarcinoma progression

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Dec 28, 2007 (publication date) through Dec 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2007; 13(48): 6478-6491
Published online Dec 28, 2007. doi: 10.3748/wjg.v13.i48.6478

Table 3 Cholangiocarcinoma marker genes with promoter putative STAT responsible elements

Cholangiocarcinoma altered genes¹	Direction of alteration¹	Putative STAT responsible elements	Regulation by STAT	References
HGF	Up	STAT3	Up	[113,114]
VEGF	Up	STAT3	Up	[157]
COX-2	Up	STAT3, STAT5	Up	[158]
Cyclin D1	Up	STAT5	Up	[16,155]
p53	Down and up	STAT1	Up	[159]
p21^waf1/cip1	Down	STAT1, STAT3, STAT5	Up	[155,160,161]
p27^kip1	Down	STAT3	Up	[162]
Bcl-2	Up	STAT3	Up	[16]
Bcl-Xl	Up	STAT3, STAT5	Up	[155,163]
Mcl-1	Up	STAT3	Up	[111,112]
MUC1	Up	STAT3, STAT1	Up	[164]
MUC4	Up	STAT	Up	[165]

¹Altered genes and direction of changes of their expression are adopted from[2].

Citation: Smirnova OV, Ostroukhova TY, Bogorad RL. JAK-STAT pathway in carcinogenesis: Is it relevant to cholangiocarcinoma progression. World J Gastroenterol 2007; 13(48): 6478-6491
URL: https://www.wjgnet.com/1007-9327/full/v13/i48/6478.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i48.6478