JAK-STAT pathway in carcinogenesis: Is it relevant to cholangiocarcinoma progression

doi:10.3748/wjg.v13.i48.6478

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Dec 28, 2007 (publication date) through Dec 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2007; 13(48): 6478-6491
Published online Dec 28, 2007. doi: 10.3748/wjg.v13.i48.6478

Table 1 Cholangiocyte receptors associated with the JAK-STAT signaling pathways: alterations of expression during cholangiocarcinoma predisposition and development

Receptor type	Norma	Direction of alteration		References
Receptor type	Norma	Cholangiocarcinoma predisposition	Cholangiocarcinoma development
Prolactin receptor	Low	Up	Up Up	References	[7,58,148]
IL-6 receptor/gp130	Present	Up	Up Up	[2,5]
ErbB-2	Low/Absent	Up	Up Up	[2,138-140]
c-Met	Present	Up	Up Up	[2,5]
Growth hormone receptor	Moderate	Up	?	[72]
Leptin receptor	Present	?	?	[85]

Citation: Smirnova OV, Ostroukhova TY, Bogorad RL. JAK-STAT pathway in carcinogenesis: Is it relevant to cholangiocarcinoma progression. World J Gastroenterol 2007; 13(48): 6478-6491
URL: https://www.wjgnet.com/1007-9327/full/v13/i48/6478.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i48.6478