Genetic and epigenetic changes associated with cholangiocarcinoma: From DNA methylation to microRNAs

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Dec 28, 2007 (publication date) through Jul 29, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2007; 13(48): 6465-6469
Published online Dec 28, 2007. doi: 10.3748/wjg.v13.i48.6465

Table 2 MicroRNAs known to be changed in cholangiocar-cinoma

MicroRNA	Targetgene	Function	Directionchangedin CCH	Reference
miR-141	CLOCK	Circadian rhythm	Increased	[16]
miR-200b	PTPN12	Tumor suppressor	Increased	[16]
miR-21	PTEN	Tumor suppressor	Increased	[16]
miR-29b	Mcl-1	Anti-apoptotic gene	Decreased	[18]
miR-370	MAP3K8	Oncogene	Decreased	[17]
let-7a	NF2	Negative regulator of inflammation	Increased	[22]

Citation: Stutes M, Tran S, DeMorrow S. Genetic and epigenetic changes associated with cholangiocarcinoma: From DNA methylation to microRNAs. World J Gastroenterol 2007; 13(48): 6465-6469
URL: https://www.wjgnet.com/1007-9327/full/v13/i48/6465.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i48.6465