Two distinct pathways of p16 gene inactivation in gallbladder cancer

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Dec 21, 2007 (publication date) through Jul 5, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Research

World J Gastroenterol. Dec 21, 2007; 13(47): 6396-6403
Published online Dec 21, 2007. doi: 10.3748/wjg.v13.i47.6396

Table 5 Association between p16 immunohistochemistry and p16 alterations in gallbladder cancers

	p16 immunohistochemistry
	Positive	Negative	P
Retension	3	3
Hypermethyaltion	9	6
LOH	1	3
LOH (multiple) + Hypermethylation	2	8
Multiple LOH	0	3
Homozygous deletion	4	9	P < 0.05

LOH: Loss of heterozygosity; Multiple LOH: LOH in 9p21 at more than two loci.

Citation: Tadokoro H, Shigihara T, Ikeda T, Takase M, Suyama M. Two distinct pathways of p16 gene inactivation in gallbladder cancer. World J Gastroenterol 2007; 13(47): 6396-6403
URL: https://www.wjgnet.com/1007-9327/full/v13/i47/6396.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i47.6396