Inflammatory cytokines suppress arylamine N-acetyltransferase 1 in cholangiocarcinoma cells

Figure 3 Effect of treatment with the nitric oxide donor GSNO on KKU-100 cells. Cell cultures were treated with 100 μmol/L GSNO for 2 and 48 h. A: Total GSH in the cells; B: GSH/GSSG ratio; C: Activity of NAT1 PABA-acetylation. Bars represent the mean ± SEM from 3 separate experiments. ^aP < 0.05 vs control groups, ^cP < 0.05 vs the 48-h treatment group.