Heterozygous nucleotide-binding oligomerization domain-2 mutations affect monocyte maturation in Crohn’s disease

Figure 4 IL-12p70 levels (pg/mL) in monocyte-culture supernatants after stimulation with LPS (■) or MDP (□) in mtNOD2 and wtNOD2 patients and healthy controls. ^aP < 0.05 LPS- vs MDP-stimulated mtNOD2 patients, LPS- vs MDP-stimulated wtNOD2 patients, LPS-stimulated mtNOD2 patients vs LPS-stimulated healthy donors, LPS-stimulated wtNOD2 patients vs LPS-stimulated healthy donors; ^bP < 0.01 LPS- vs MDP-stimulated healthy donors; Student’s t test.