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©2007 Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 14, 2007; 13(46): 6254-6258
Published online Dec 14, 2007. doi: 10.3748/wjg.v13.i46.6254
Published online Dec 14, 2007. doi: 10.3748/wjg.v13.i46.6254
Table 3 Germline mutations of MLH1
| Families | Genes | Exon | Codons affected | DNA change | Amino acid change | Mutation types |
| H2 | MLH1 | 8 | 217 | C→T, at 649 | Arg→Cys | Missense |
| H31 | MLH1 | 16 | 581 | C→T, at 1742 | Pro→Leu | Missense |
| H109 | MLH1 | 12 | 384 | T→A, at 1151 | Val→Asp | Missense |
| H114 | MLH1 | 12 | 384 | T→A, at 1151 | Val→Asp | Missense |
- Citation: Wang CF, Zhou XY, Zhang TM, Xu Y, Cai SJ, Shi DR. Two novel germline mutations of MLH1 and investigation of their pathobiology in hereditary non-polyposis colorectal cancer families in China. World J Gastroenterol 2007; 13(46): 6254-6258
- URL: https://www.wjgnet.com/1007-9327/full/v13/i46/6254.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i46.6254