Telbivudine: A new treatment for chronic hepatitis B

Table 3 Efficacy at 2 yr in HBeAg positive and HBeAg negative individuals in the Globe study receiving Telbivudine or lamivudine

	Telbivudine	Lamivudine	P value
HBeAg positive patients
HBV DNA fall (mean log10)	-5.7	-4.4	< 0.05
HBV DNA non-detectable by PCR (%)	54	38	< 0.05
Treatment failure (%)1	4	12.3	< 0.05
HBeAg negative patients
HBV DNA fall (mean log10)	-5	-4.2	< 0.05
HBV DNA non-detectable by PCR (%)	79	53	< 0.05
Treatment failure (%)1	0	3	< 0.05

¹Defined as HBV DNA > 5 log10 copies/mL.