Telbivudine: A new treatment for chronic hepatitis B

Table 1 Efficacy at 1 yr in HBeAg positive and HBeAg negative individuals in the Globe study receiving telbivudine or lamivudine

	Telbivudine	Lamivudine	P value
HBeAg positive patients
HBV DNA fall (mean log10)	-6.5	-5.5	< 0.01
HBV DNA non-detectable by PCR (%)	60	40	< 0.01
Treatment failure (%)1	5	13	< 0.01
HBeAg negative patients
HBV DNA fall (mean log10)	-5.2	-4.4	< 0.01
HBV DNA non-detectable by PCR (%)	88	71	< 0.01
Treatment failure (%)1	< 1	3	NS

¹Defined as HBV DNA > 5 log₁₀ copies/mL.