NAT2*6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis

Table 5 Distribution of NAT2-diplotypes in TB patients with and without adverse effect

	Hepatotoxicity					Skin rash					Eosinophilia
Diplotype	Present(%)	Absent(%)	OR	95% CI	P	Present(%)	Absent(%)	OR	95% CI	P	Present(%)	Absent(%)	OR	95% CI	P
NAT2*4/*4	4 (22.2)	42 (51.2)	0.272	0.083-0.897	0.032	12 (48.0)	34 (45.3)	1.113	0.449-2.757	0.817	14 (41.2)	32 (48.5)	0.744	0.322-1.717	0.488
NAT2*4/*6A	7 (38.9)	23 (28.1)	1.632	0.564-4.726	0.366	7 (28.0)	23 (30.7)	0.879	0.323-2.394	0.801	11 (32.4)	19 (28.9)	1.183	0.484-2.894	0.713
NAT2*4/*7B	1 (5.6)	13 (15.9)	0.312	0.038-2.555	0.278	3 (12.0)	11 (14.7)	0.793	0.203-3.108	0.740	6 (17.6)	8 (12.1)	1.554	0.492-4.909	0.453
NAT2*6A/*6A	2 (11.1)	2 (2.4)	5.000	0.655-38.152	0.121	2 (8.0)	2 (2.7)	3.174	0.423-23.812	0.261	1 (2.9)	3 (4.5)	0.636	0.064-6.360	0.700
NAT2*6A/*7B	3 (16.6)	2 (2.4)	8.000	1.230-52.023	0.029	1 (4.0)	4 (5.3)	0.74	0.079-6.945	0.792	2 (5.9)	3 (4.5)	1.313	0.209-8.257	0.772
NAT2*7B/*7B	1 (5.6)	0 (0)	-	-	-	0 (0)	1 (1.3)	-	-	-	0 (0)	1 (1.5)	-	-	-
Total number	18	82				25	75				34	66