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©2007 Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 7, 2007; 13(45): 6003-6008
Published online Dec 7, 2007. doi: 10.3748/wjg.v13.i45.6003
Published online Dec 7, 2007. doi: 10.3748/wjg.v13.i45.6003
Table 4 Distributions of NAT2-haplotypes in TB patients with and without adverse effect
| Hepatotoxicity | Skin rash | Eosinophilia | |||||||||||||
| Haplotype | Present(%) | Absent(%) | OR | 95% CI | P | Present(%) | Absent(%) | OR | 95% CI | P | Present(%) | Absent(%) | OR | 95% CI | P |
| NAT2*4 | 16 (44.4) | 120 (73.2) | 0.265 | 0.129-0.546 | < 0.001 | 34 (68.0) | 102 (68.0) | 1.00 | 0.503-1.987 | 1.000 | 45 (66.2) | 91 (68.9) | 0.880 | 0.472-1.642 | 0.688 |
| NAT2*6A | 14 (38.9) | 29 (17.7) | 3.535 | 1.648-7.585 | 0.001 | 12 (24.0) | 31 (20.7) | 1.22 | 0.570-2.607 | 0.609 | 15 (22.0) | 28 (21.2) | 1.052 | 0.517-2.138 | 0.889 |
| NAT2*7B | 6 (16.7) | 15 (9.1) | 2.235 | 0.818-6.104 | 0.117 | 4 (8.0) | 17 (11.3) | 0.70 | 0.226-2.170 | 0.537 | 8 (11.8) | 13 (9.9) | 1.227 | 0.482-3.124 | 0.667 |
| Total number | 36 | 164 | 50 | 150 | 68 | 132 | |||||||||
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Citation: Higuchi N, Tahara N, Yanagihara K, Fukushima K, Suyama N, Inoue Y, Miyazaki Y, Kobayashi T, Yoshiura KI, Niikawa N, Wen CY, Isomoto H, Shikuwa S, Omagari K, Mizuta Y, Kohno S, Tsukamoto K.
NAT2*6A , a haplotype of theN -acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis. World J Gastroenterol 2007; 13(45): 6003-6008 - URL: https://www.wjgnet.com/1007-9327/full/v13/i45/6003.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i45.6003