NAT2*6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis

Table 3 Clinical characteristics and laboratory data of TB patients with or without adverse effect

	Hepatotoxicity			Skin rash			Eosinophilia
Clinical data	Present	Absent	P	Present	Absent	P	Present	Absent	P
	(n = 18)	(n = 82)		(n = 25)	(n = 75)		(n = 34)	(n = 66)
Age (mean ± SD)	60.8 ± 17.7	64.7 ± 17.3	0.3942	63.6 ± 18.1	64.7 ± 17.3	0.9028	63.3 ± 19.5	64.4 ± 16.3	0.7598
Gender (M/F)	9/9	47/35	0.6081	12/13	44/31	0.3640	25/9	31/35	0.0186
Body mass index (kg/m2)	19.6 ± 2.3	20.5 ± 3.1	0.2721	19.8 ± 2.5	20.6 ± 3.1	0.2626	19.8 ± 2.9	20.6 ± 3.0	0.2684
Baseline values
ALT (IU/L)	18.0 ± 10.4	21.1 ± 16.6	0.4527	23.1 ± 25.8	19.7 ± 10.4	0.3392	25.9 ± 24.4	17.8 ± 6.8	0.6571
AST (IU/L)	29.1 ± 26.8	26.8 ± 23.3	0.7188	31.3 ± 39.2	25.9 ± 15.9	0.3268	35.4 ± 38.5	23.0 ± 7.8	0.4277
TB (mg/dL)	0.48 ± 0.19	0.64 ± 0.43	0.1115	0.61 ± 0.44	0.61 ± 0.39	0.9874	0.62 ± 0.44	0.61 ± 0.38	0.9490
Creatinine (mg/dL)	0.64 ± 0.13	0.88 ± 1.10	0.3482	0.72 ± 0.28	0.87 ± 1.13	0.5121	0.82 ± 0.47	0.84 ± 1.17	0.9092
Eosinophils (/μL)	105.1 ± 120.6	115.5 ± 121.8	0.7434	104.7 ± 93.7	116.6 ± 129.3	0.6750	141.3 ± 133.4	99.3 ± 112.6	0.1011
During TB chemotherapy
Peak ALT (IU/L)	316.2 ± 281.7	40.0 ± 19.5	< 0.0001	147.8 ± 281.7	61.6 ± 88.1	0.0245	129.6 ± 284.1	59.2 ± 75.4	0.3885
Peak AST (IU/L)	294.5 ± 353.6	36.7 ± 21.5	< 0.0001	139.7 ± 222.9	73.1 ± 128.9	0.1325	116.3 ± 175.9	76.0 ± 149.3	0.2107
Peak TB (mg/dL)	1.20 ± 1.16	0.74 ± 0.53	0.0101	0.78 ± 0.47	0.84 ± 0.77	0.7039	0.92 ± 0.89	0.77 ± 0.58	0.3241
Peak Creatinine (mg/L)	0.76 ± 0.13	0.96 ± 1.23	0.4742	0.81 ± 0.13	0.97 ± 1.28	0.5316	0.87 ± 0.31	0.96 ± 1.36	0.7098
Peak Eosinophils (/μL)	692.4 ± 929.1	461.1 ± 844.7	0.4538	668.4 ± 773.9	447.5 ± 885.1	0.0058	1028.1 ± 1327.9	232.1 ± 114.9	< 0.0001