Comprehensive screening for reg1α gene rules out association with tropical calcific pancreatitis

Table 6 Distribution of reg1α gene polymorphisms in tropical calcific pancreatitis patients based on N34S SPINK1 and L26V CTSB status

SNP	SPINK1 mutation				CTSB mutation
	Minor allele frequency1		OR (95% CI)	P value	Minor allele frequency2		OR (95% CI)	P value
	N34S (n = 48)	WILD (n = 82)			L26V (n = 105)	WILD (n = 73)
G-938A	0.33	0.34	0.96 (0.51-1.79)	0.88	0.34	0.31	1.15 (0.61-2.16)	0.65
T-912G	0.49	0.45	1.17 (0.65-2.13)	0.57	0.43	0.54	0.64 (0.35-1.17))	0.12
T-385C	0.31	0.33	0.91 (0.48-1.73)	0.76	0.31	0.26	1.28 (0.66-2.48)	0.43
T-243G	0.33	0.39	0.77 (0.41-1.43)	0.38	0.34	0.31	1.15 (0.61-2.16)	0.65
G209T	0.18	0.21	0.83 (0.39-1.76)	0.59	0.23	0.19	1.27 (0.61-2.66)	0.49
G2199A	0.34	0.35	0.96 (0.51-1.79)	0.88	0.38	0.27	1.66 (0.87-3.15)	0.10

SNP: Single nucleotide polymorphism; n: Number of individuals; OR: Odds ratio; CI: Confidence interval;

¹Minor allele frequency based on N34S SPINK1 status;

²Allele frequency based on L26V CTSB status.