Stability of cirrhotic systemic hemodynamics ensures sufficient splanchnic blood flow after living-donor liver transplantation in adult recipients with liver cirrhosis

Table 1 Systemic hemodynamic parameters, K_ICG values and splanchnic circulatory parameters before LDLT

Parameters	Healthy individuals n = 16	Group I n = 25	Group II n = 5
Systemic hemodynamics
CO (L/min)	5.83 ± 1.52	6.87 ± 0.97a	7.36 ± 1.07e
CI (L/min per m2)	3.22 ± 0.71	4.10 ± 0.71b	4.56 ± 0.58e
BV (L)	3.40 ± 0.96	4.09 ± 0.51a	4.40 ± 0.45e
CO/BV (/min)	1.74 ± 0.28	1.69 ± 0.21	1.69 ± 0.28
MTT (s)	16.1 ± 2.3	16.5 ± 1.5	16.5 ± 1.2
HR (beat/min)	64.3 ± 9.9	77.9 ± 12.6b	77.6 ± 9.8e
MAP (mmHg)	89.3 ± 11.8	68.9 ± 6.5d	70.8 ± 11.2e
TPR (dyne/s5 per cm)	1275.1 ± 228.3	818.9 ± 166.7d	785.3 ± 187.4e
ICG clearance test
KICG	0.227 ± 0.076	0.037 ± 0.017d	0.056 ± 0.038e
Splanchnic circulation
Portal vein
PVFVo (mL/min)	1482.1 ± 335.6	327.3 ± 416.9d	435.6 ± 592.6e
PVFVe (cm/s)	45.1 ± 8.1	7.9 ± 12.8d	10.5 ± 13.8f
Hepatic artery
HAPI	0.95 ± 0.11	1.06 ± 0.28a	1.16 ± 0.21e
HARI	0.93 ± 0.26	1.04 ± 0.23a	1.10 ± 0.10e

There were no significant differences between Groups I and II in each parameter, respectively (P > 0.05, analyzed by Mann-Whitney’s U test ). Statistical differences between healthy individuals and Group I analyzed by Mann-Whitney’s U test (^aP < 0.05,

^bP < 0.005,

^dP < 0.0005). Statistical differences between healthy individuals and Group II analyzed by Mann-Whitney’s U test (^eP < 0.05,

^fP < 0.005). ICG: Indocyanine green; LDLT: Living-donor liver transplantation; CO: Cardiac output; CI: Cardiac index; BV: Blood volume; MTT: Mean transit time; HR: Heart rate; MAP: Mean arterial pressure; TPR: Total peripheral resistance; PVFVo: Portal veinous flow volume; PVFVe: Portal venous flow velocity; HAPI: Hepatic arterial pulsatility index; HARI: Hepatic arterial resistant index.