Genetic polymorphisms of ADH2 and ALDH2 association with esophageal cancer risk in southwest China

Table 3 Combined effect of alcohol consumption and ADH2 and ALDH2 polymorphisms on esophageal cancer n (%)

ADH2		Alcohol drinking status
		Non-drinkers2			Current alcohol drinkers
		Cases (n = 80)	Controls (n = 128)	OR (95% CI)1	Cases (n = 111)	Controls (n = 70)	OR (95% CI)1
*2/*2		37 (46.3)	65 (50.8)	1.00 (References)	41 (36.9)	35 (50.0)	1.88 (0.86-4.15)
*1/*2 or *1/*1		43 (53.7)	63 (49.2)	1.21 (0.63-2.33)	70 (63.1)	35 (50.0)	3.94 (1.76-8.81)
ALDH2
*1/*1		33 (41.3)	67 (52.3)	1.00 (References)	57 (51.4)	41 (58.6)	3.15 (1.39-7.13)
*1/*2 or *2/*2		47 (58.7)	61 (47.7)	2.03 (1.03-3.99)	54 (48.6)	29 (41.4)	4.82 (2.06-11.27)
ADH2 and ALDH2
*2/*2	*1/*1	15 (18.8)	42 (32.8)	1.00 (References)	17 (15.3)	20 (28.6)	2.54 (0.84-7.67)
*1/*2 or *1/*1	*1/*2 or *2/*2	25 (31.3)	38 (29.7)	2.46 (0.98-6.14)	30 (27.0)	14 (20.0)	9.86 (3.10-31.38)

¹ORs were adjusted for sex, age, smoking, rapid food eating, quality of drinking water, consumption of picked vegetables and fresh fruits, vegetables and eggs;

²Non-drinkers including ex-drinkers.