Genetic polymorphisms of ADH2 and ALDH2 association with esophageal cancer risk in southwest China

Table 2 ADH2, ALDH2 genotype and allele frequencies and ORs for esophageal cancer n (%)

ADH2	Cases (n = 191)	Controls (n = 198)	OR (95% CI)1
*2/*2	78 (40.8)	100 (50.5)	1.00 (Reference)
*1/*2	80 (41.9)	76 (38.4)	1.89 (1.10-3.22)
*1/*1	33 (17.3)	22 (11.1)	1.91 (0.92-3.95)
*1/*2 + *1/*1	113 (59.2)	98 (49.5)	1.65 (1.02-2.68)
ALDH2
*1/*1	90 (47.1)	108 (54.5)	1.00 (References)
*1/*2	98 (51.3)	76 (38.4)	1.67 (1.02-2.72)
*2/*2	3 (1.6)	14 (7.1)	0.26 (0.06-1.09)
*1/*2 + *2/*2	101 (52.9)	90 (45.5)	1.43 (0.89-2.30)
Allele frequencies			OR (95% CI)2
ADH2
*2	236 (61.8)	276 (69.7)	1.00 (References)
*1	146 (38.2)	120 (30.3)	1.42 (1.06-1.92)
ALDH2
*1	278 (72.8)	292 (73.7)	1.00 (References)
*2	104 (27.2)	104 (26.3)	1.05 (0.76-1.44)

¹ORs for gene frequencies were adjusted for sex, age, smoking, drinking, rapid food eating, quality of drinking water, consumption of fresh fruits, vegetable and eggs;

²ORs for allele frequencies were not adjusted.