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©2007 Baishideng Publishing Group Inc.
World J Gastroenterol. Nov 21, 2007; 13(43): 5725-5730
Published online Nov 21, 2007. doi: 10.3748/wjg.v13.i43.5725
Published online Nov 21, 2007. doi: 10.3748/wjg.v13.i43.5725
Table 4 Interaction between the CYP2E1 genotype and the status of smoking and alcohol drinking, and the odds ratios (ORs) for colorectal cancer
| CYP2E1 genotype | Controls n | Colorectal cancer | Colon cancer | Rectal cancer | ||||
| n | OR1 (95% CI) | n | OR1 (95% CI) | n | OR1 (95% CI) | |||
| Smoker | ||||||||
| No | c1/c1 + c1/c2 | 275 | 162 | 1.00 | 57 | 1.00 | 105 | 1.00 |
| No | c2/c2 | 5 | 14 | 2.20 (1.31-3.70) | 4 | 1.95 (0.99-3.86) | 10 | 2.30 (1.32-3.99) |
| Yes | c1/c1 + c1/c2 | 145 | 129 | 1.34 (0.93-1.92) | 41 | 1.11 (0.66-1.88) | 88 | 1.48 (0.98-2.25) |
| Yes | c2/c2 | 8 | 8 | 1.41 (0.50-3.96) | 2 | 0.91 (0.18-4.57) | 6 | 1.75 (0.57-5.42) |
| Drinker | ||||||||
| No | c1/c1 + c1/c2 | 313 | 174 | 1.00 | 62 | 1.00 | 112 | 1.00 |
| No | c2/c2 | 9 | 10 | 1.41 (0.89-2.24) | 2 | 1.09 (0.50-2.38) | 8 | 1.55 (0.95-2.53) |
| Yes | c1/c1 + c1/c2 | 107 | 117 | 1.86 (1.28-2.68) | 36 | 1.50 (0.89-2.55) | 81 | 2.07 (1.37-3.14) |
| Yes | c2/c2 | 4 | 12 | 5.42 (1.65-17.40) | 4 | 4.74 (1.10-20.40) | 8 | 5.75 (1.65-20.05) |
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Citation: Gao CM, Takezaki T, Wu JZ, Chen MB, Liu YT, Ding JH, Sugimura H, Cao J, Hamajima N, Tajima K.
CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking. World J Gastroenterol 2007; 13(43): 5725-5730 - URL: https://www.wjgnet.com/1007-9327/full/v13/i43/5725.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i43.5725