Constitutive androstane receptor agonist, TCPOBOP, attenuates steatohepatitis in the methionine choline-deficient diet-fed mouse

Figure 4 Hepatic inflammation attenuated by TCPOBOP treatment in the MCD diet-fed mice. Top panel: Representative photomicrographs of immunohistochemistry for CD68, a marker of Kupffer cells; Lower panel: The percentage of CD68-positive areas in the liver sections was quantitated using digital image analysis. Immunoreactivity for CD68 was significantly reduced in TCPOBOP-treated MCD diet-fed mice as compared with vehicle- and androstanol-treated mice (^bP = 0.002) (n = 5 in each group).