Constitutive androstane receptor agonist, TCPOBOP, attenuates steatohepatitis in the methionine choline-deficient diet-fed mouse

Figure 3 Hepatocyte apoptosis is attenuated by TCPOBOP in the MCD-diet fed animal. (A and B) Fixed liver specimens were analyzed by TUNEL and immunofluorescence for active caspase 3/7 to identify apoptotic liver cells. The percent/field area of TUNEL- (^bP = 0.01) and active caspase 3/7-positive cells (^aP = 0.03) were significantly higher in vehicle-treated MCD diet-fed mice than TCPOBOP-treated (3 mg/kg ip for 3d) MCD diet-fed mice (n = 5 in each group).