Influence of a nucleotide oligomerization domain 1 (NOD1) polymorphism and NOD2 mutant alleles on Crohn's disease phenotype

Table 3 Distribution of NOD2 mutations in CD patients and controls

NOD2 genotype	CD Patients,n (%)	Controls,n (%)	OR (95% CI)1	P2
At least one variant3	30 (30.92)	3 (6)	7.01 (2.02-24.30)	< 0.001
Heterozygous	24 (24.74)	3 (6)	5.61 (1.59-19.0)	0.003
Compound heterozygous4	5 (5.15)	0
Homozygous	1 (1.03)	0

¹ORs and probability values for disease status associated with NOD2 genotype. ²P-values are calculated with the Fisher's Exact test when comparing controls and CD patients.

³At least one variant was considered if any subject had at least one copy of the variant allele.

⁴Compound heterozygous was defined as the presence of two different variants.