Chinese medicinal compound delisheng has satisfactory anti-tumor activity, and is associated with up-regulation of endostatin in human hepatocellular carcinoma cell line HepG2 in three-dimensional culture

Table 4 Endostatin expression of multicellular spheroids with treatment of delisheng, 5-fluorouracil, adriamycin and PBS

Drug	Mean grey value
Delisheng	139.35 ± 7.83
5-fluorouracila	159.23 ± 10.34
Adriamycinc	162.83 ± 3.47
PBSe	148.48 ± 11.06

^aP < 0.05 5-fluorouracil vs delisheng,

^cP < 0.05 adriamycin vs delisheng,

^eP < 0.05 PBS vs delisheng.