Protection of Veratrum nigrum L. var. ussuriense Nakai alkaloids against ischemia-reperfusion injury of the rat liver

Figure 1 Changes of histology in the liver tissue 90 min after ischemia and 240 min after reperfusion in rats (× 400). Five μm sections of liver tissue were stained with hematoxylin and eosin according to standard procedures. For all groups, n = 10. A: Control group: Normal appearance of hepatocytes and sinusoids; B: I/R group: Histological edema, hemorrhage, partial exfoliation of blood vessel endothelium and infiltration with inflammatory cells; C: I/R + VnA (10 μg/kg) group: A significant amelioration of histological edema, hemorrhage, and exfoliation of blood vessel endothelium; D: I/R + VnA (20 μg/kg) group: Slight inflammatory cell infiltration with most hepatocytes in normal appearance.