Impact of tiny miRNAs on cancers

Figure 2 The positive loop between mir-16 and LIN-12. Exogenous signal activates LIN-12/Notch signaling pathway, which promotes the transcription of mir-61. Overexpression of mir-61 inhibits the activity of VAV-1 (purple) that reduces the activity of LIN-12 (pink), where LIN-12, mir-61, and VAV-1 form a feedback loop that helps maximize LIN-12 activity.