Sequential algorithms combining non-invasive markers and biopsy for the assessment of liver fibrosis in chronic hepatitis B

Table 3 Performance of the non-invasive methods and of the algorithm B in detecting cirrhosis (F4 by METAVIR) in patients with CHB

	Fibrotest	APRI	AAR	GUCI	Algorithm B
Classified cases (%)	100	66.2	100	100	100
Cut-off	F4	2	1	1	na
Sensitivity (%)	55.6	42.9	7.1	21.4	92.9
Specificity (%)	96.3	85.4	94.7	91.2	96.5
PPV (%)	90	53.8	82.4	73.7	87.5
NPV (%)	87.1	91.1	81.4	83.8	98.3
LR +	15	2.94	1.34	2.43	26.5
LR -	0.46	0.67	0.98	0.86	0.07
Accuracy (%)	86.1	79.2	77.5	77.5	95.8
AUC (95% CI)	0.76 (0.67-0.85)	0.64 (0.53-0.75)	0.51 (0.39-0.62)	0.56 (0.47-0.65)	0.95 (0.90-1)