Expression of periostin and its clinicopathological relevance in gastric cancer

Figure 3 Immunohistochemical analysis of periostin expression in normal gastric tissues, benign gastric ulcers, gastric cancer tissues, as well as lymphoid metastasis from gastric cancer. The tissue sections were immunostained with a polyclonal antibody. The positive staining for periostin protein is shown with a brown color. All sections were counterstained with hematoxylin showing a blue color. (A) Negative control; (B) benign gastric ulcer; (C) stageIgastric cancer; (D) stageIIgastric cancer; (E) stage III gastric cancer; (F) stage IV gastric cancer; (G) lymph node metastasis. The average MOD of periostin staining from stageI-IV gastric cancer was significantly higher than that from normal gastric tissues in each group (H) (P < 0.05).