Fever as the only manifestation of hypersensitivity reactions associated with oxaliplatin in a patient with colorectal cancer Oxaliplatin-induced hypersensitivity reaction

Table 3 Characteristics of HSR with different Platinum compounds

	Cisplatinum[12,13]	Carboplatinum[4,15]	Oxaliplatin[5-9]
Incidence	5%-20% ( Increased with radiation)	16%	12% (14), < 1% grade 3-4
Initial onset	-	After 6 cycles( range 2-12)	After 7 cycles ( range 2-25)
Time of onset	Minutes	Minutes-days	Minutes-hours
Symptoms	Variable( fever, anxiety, pruritus, cough, dyspnea, diaphoresis, angioedema, vomiting, bronchospasm, rash and pruritus, and hypotension	Variable (itching ,rash, chest tightness, Blood pressure changes, facial swelling)	Variable (flushing, alterations in heart rate, dyspnea, back pain, fever, pruritis, erythema, nausea, rash)
Can it be re-introduced?	-	Yes, with slowing the infusion rate (6% discontinued)	Yes, with pre-medications, slowing the infusion rate, and/or desensitization