Crohn’s disease incidence evolution in North-western Greece is not associated with alteration of NOD2/CARD15 variants

Table 3 CARD15 variant allele frequencies

	Genotype			Mutant allelefrequency (%)	P; OR (95% CI)
Samples	-/-	-/+	+/+
R702W
CD	85	8	3	7.29	0.015; 3.85 (1.24-11.93)
UC	171	9	0	2.5	0.78; 1.26 (0.38-4.13)
Control	96	4	0	2
G908R
CD	83	13	0	6.77	0.70; 0.83 (0.39-1.78)
UC	156	24	0	6.66	0.61; 0.82 (0.42-1.58)
Control	84	16	0	8
Leu1007fsincC
CD	52	36	8	27.08	< 0.0001; 7.06 (3.46-14.37)
UC	166	9	5	5.27	1; 1.06 (0.48-2.32)
Control	90	10	0	5

-/-, homozygous wild-type; -/+, heterozygous; +/+, homozygous mutant. CD: Crohn’s disease; UC: Ulcerative colitis; OR: Odds Ratio; CI: Confidence Interval. The CARD15 gene variants determined in 96 CD patients (from 102 living CD patients out of 105, from our cohort 6 refused genetic test), 180 out of 300 living UC patients and 100 randomly chosen healthy blood donors.