Three novel missense germline mutations in different exons of MSH6 gene in Chinese hereditary non-polyposis colorectal cancer families

Figure 2 Missense germline mutation of exon 4. 6 of MSH6 gene in the proband of H40 HNPCC kindreds. Arrow indicates the mutation site, The single basyl substitution was transvered from T to C (T>C) at the codon 666, the codon from TCT to CCT, causing the amiod acid changes from serine to proline. A and B represent the forward and reverse sequence, respectively.