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©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Oct 7, 2007; 13(37): 4967-4973
Published online Oct 7, 2007. doi: 10.3748/wjg.v13.i37.4967
Published online Oct 7, 2007. doi: 10.3748/wjg.v13.i37.4967
Figure 2 Overlapping alterations to the liver mitochondrial proteome contribute to the development of alcohol-induced liver disease.
This figure illustrates the concept that there is a unique mitochondrial sub-proteome that when altered by chronic alcohol mediated mtDNA/ribosome damage, increased ROS/RNS production, and energy deficits contribute to the development of alcohol hepatotoxicity. These alterations involve changes in both protein levels (panel A) and post-translational modifications (PTMs, panel B) to this susceptible population of mitochondrial proteins.
- Citation: Mantena SK, King AL, Andringa KK, Landar A, Darley-Usmar V, Bailey SM. Novel interactions of mitochondria and reactive oxygen/nitrogen species in alcohol mediated liver disease. World J Gastroenterol 2007; 13(37): 4967-4973
- URL: https://www.wjgnet.com/1007-9327/full/v13/i37/4967.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i37.4967