Three novel missense germline mutations in different exons of MSH6 gene in Chinese hereditary non-polyposis colorectal cancer families

doi:10.3748/wjg.v13.i37.5021

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Oct 7, 2007 (publication date) through Jul 20, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2007; 13(37): 5021-5024
Published online Oct 7, 2007. doi: 10.3748/wjg.v13.i37.5021

Table 3 Clinical characteristics of 4 mutational probands of HNPCC families

No	Sex	Age(yr)	Criteria	Site of cancer	Age at diagnosis of first CRC (yr)	Metachronous tumor
H3	M	50	AC	Sigmoid	46	VA
H14	F	26	BG	Rectum	26	NMT
H40	F	39	BG	Rectum	39	NMT
H61	F	51	BG	Descending	33	EC

Abbreviation: AC, Amsterdam criteria. JC, Japanese criteria. BG, Bethesda guidelines. CRC, Colorectal cancer. VA, Villiform adenoma. NMT: No Metachronous tumor. EC, Endometrial cancer.

Citation: Yan SY, Zhou XY, Du X, Zhang TM, Lu YM, Cai SJ, Xu XL, Yu BH, Zhou HH, Shi DR. Three novel missense germline mutations in different exons of MSH6 gene in Chinese hereditary non-polyposis colorectal cancer families. World J Gastroenterol 2007; 13(37): 5021-5024
URL: https://www.wjgnet.com/1007-9327/full/v13/i37/5021.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i37.5021