Protective effects of ursodeoxycholic acid on chenodeoxycholic acid-induced liver injury in hamsters

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Oct 7, 2007 (publication date) through Jul 17, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2007; 13(37): 5003-5008
Published online Oct 7, 2007. doi: 10.3748/wjg.v13.i37.5003

Table 2 Effect of UDCA on histological extent of CDCA-induced liver injury in hamsters

		Grade
	Findings	-	±	+
Normal	Vacuolation (Hydropic swelling)	9	0	0
Control		0	2	7
UDCA 150 mg/kg		9	0	0
Normal		8	1	0
Control	Cell infiltration	8	1	0
UDCA 150 mg/kg		7	2	0
Normal		8	1	0
Control	Focal necrosis	8	1	0
UDCA 150 mg/kg		7	2	0

UDCA: Ursodeoxycholic acid; CDCA: Chenodeoxycholic acid. Grades are as follows: -: no change, ±: slight change, +: mild change.

Citation: Iwaki T, Ishizaki K, Kinoshita S, Tanaka H, Fukunari A, Tsurufuji M, Imada T. Protective effects of ursodeoxycholic acid on chenodeoxycholic acid-induced liver injury in hamsters. World J Gastroenterol 2007; 13(37): 5003-5008
URL: https://www.wjgnet.com/1007-9327/full/v13/i37/5003.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i37.5003