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World J Gastroenterol. Sep 21, 2007; 13(35): 4746-4754
Published online Sep 21, 2007. doi: 10.3748/wjg.v13.i35.4746
Published online Sep 21, 2007. doi: 10.3748/wjg.v13.i35.4746
Figure 1 The involvement of iron in oxidative stress and its cytotoxic conse-quences.
Iron catalyses the production of the reactive molecules OH• (via the Fenton reaction) and NO2+, which promote lipid peroxidation and protein damage leading to cellular injury. NOS, nitric oxide synthase; •NO, nitric oxide; ONOO-, peroxynitrite; O2•-, superoxide radical; OH•, hydroxyl radical; H2O2, hydrogen peroxide; NO2+, nitronium anion; Fe, iron; NAFLD, non-alcoholic fatty liver disease.
- Citation: Philippe MA, Ruddell RG, Ramm GA. Role of iron in hepatic fibrosis: One piece in the puzzle. World J Gastroenterol 2007; 13(35): 4746-4754
- URL: https://www.wjgnet.com/1007-9327/full/v13/i35/4746.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i35.4746