Pathology of hepatic iron overload

Table 2 Histological grades of iron storage from Deugnier Y and Turlin B[3-12]

Hepatocytic iron	0, 3, 6, 9 or 12	HIS
	According granules size	0-36
	In each Rappaport area
Sinusoidal iron	0, 1, 2, 3 or 4	SIS
	According granules size	0-12
	In each Rappaport area
Portal iron	0, 1, 2, 3 or 4	PIS
	According to % of iron overloaded macrophages,	0-12
	biliary cells, and vascular walls
Total iron score		0-60

HIS: hepatocytic iron score; SIS: sinusoidal iron score; PIS: portal iron score.