HFE gene in primary and secondary hepatic iron overload

Table 4 Studies of the relationship between NAFLD-NASH, iron and HFE mutations

Reference	Casesn	Ethnicity	HFErelationshipwith serumiron indices	HFErelationshipwith HI	HFErelationshipwithfibrosis
[139]	51	Australian	Yes with transferrin saturation, no with ferritin	Yes	Yes
[142]	31	Italian	No	Yes	No
[146]	263	Italian	Yes (C282Y)	No	No
[151]	57	Caucasian	Yes	Yes	Yes
[152]	32	Mostly Caucasian	No	No	No
[153]	38	Asian	No	No	No
[154]	31	Asian Indian	No	No	No
[155]	93	Mostly Caucasian	No	Yes	No

NA: not available; HI: hepatic iron (histological and/or biochemical evidence).