Matrix metalloproteinase-9-1562C>T polymorphism may increase the risk of lymphatic metastasis of colorectal cancer

Table 2 MMP-9 genotypes and the risk of CRC n (%)

Genotypes	Controls	Cases	OR1 (95% CI)
C-1562T
CC	147 (73.9)	104 (75.9)	1.00
CT	47 (23.6)	33 (24.1)	0.877 (0.527-1.462)
TT	5 (2.5)	0 (0)
T allele	0.143	0.12
R279Q
QQ	16 (8.0)	12 (8.8)	1.00
RQ	85 (42.7)	58 (42.3)	0.936 (0.410-2.138)
RR	98 (49.2)	67 (48.9)	0.961 (0.424-2.177)
R allele	0.706	0.701
C-1562T and R279Q combinations
279 QQ and -1562CC	11 (5.5)	9 (6.6)	1.00
1-2 risk alleles2	155(77.9)	109 (79.6)	1.357 (0.474-3.886)
> 2 risk alleles	33 (16.6)	19 (13.9)	1.227 (0.661-2.277)

¹OR for CT/TT genotypes versus CC genotypes and adjusted for age, gender, smoking status, alcohol consumption and body mass index.

²Risk alleles were MMP-9 279R and -1562T.