Changes in gene-expression profiles of colon carcinoma cells induced by wild type K-ras2

Table 1 Biological function of genes with down-regulated expression

Gene	Chromosomal localization	Biological function	Cy5/Cy3
NDP	Xp11.4	Cross-cell signal transmission, signal transduction, NS development	4.509
SSX4	Xp11.23	Transcription regulation, immunoreaction	4.044
CASP1	11q23	Positive regulation of I-kappaB kinase/NF-kappaB cascadereaction, signal transduction, apoptosis	3.754
HPRT1	Xq26.1	Cytolysis, lymphocyte proliferation, purine nucleotide synthesis	3.715
TM4SF2	Xp11.4	ECM	3.554
DXS1283E	Xp22.3	Unkown	3.418
DPYS	8q22	NS development, signal transduct-ion, nucleotide metabolism	3.386
TYRP1	9p23	Cell metabolism, melanin synthesis	3.358
CADPS	3p21.1	Calcium-regulated Exocytosis	3.238
MCF2	Xq27	Cytokeleton	3.187
COL4A6	Xq22	ECM and ECM synthesis	3.201
F13A1	6p25.3-p24.3	Transcriptional control	3.108
HTR2C	Xq24	IP3-induced signal pathway	3.061
IL13RA1	Xq24	ECM	3.050
OGT	Xq13	Signal transduction	3.030
TOSO	1q32.1	Defence reaction, anti-apoptosis	2.994
MAB21L1	13q13	Positive regulation of cell proliferation, visual development	2.990
CYBB	Xp21.1	Cross-cell signal transmission, chemotaxis, inflammation, signal transduction	2.972
STK9/CDKL5	Xp22	Microduct skeleton and its synthesis, histogenesis	2.946
PTPRG	3p21-p14	PTK signal pathway	2.878
ELAVL2	9p21	Transcriptional control	2.853
GLA	Xq22	Osteoclast differentce regulation,bone resorption, cell adhere	2.851
APXL	Xp22.3	Channel protein of sodium ion	2.839
SERPINA7	Xq22.2	ECM, transport of TH	2.833