Evidence for the role of gastric mucosa at the secretion of soluble triggering receptor expressed on myeloid cells (strem-1) in peptic ulcer disease

Table 2 Concentrations of soluble triggering receptor expressed on myeloid cells-s (sTREM-1) and tumor necrosis factor-alpha (TNFα) of supernatants of tissue samples taken from patients with either duodenal or gastric ulcer disease or chronic gastritis at pre-treatment

Parameters	Duodenal ulcer		Gastric ulcer		Chronic Gastritis
	H pylori (+)	H pylori (-)	H pylori (+)	H pylori (-)	H pylori (+)	H pylori (-)
N	35	0	14	7	9	7
sTREM-1 [median (range), pg/g of tissue]
0	32.41 (13.32)	-	317.27 (73.98)a	112.41 (38.71)	6.21 (0.81)c	5.18 (0.77)
LPS	102.41 (40.43)	-	455.41 (98.53)b	214.55 (44.81)	12.67 (2.16)c	9.37 (1.55)
Gastric juice	17.91 (7.11)	-	150.14 (41.16)c	118.48 (54.93)	10.07 (2.02)c	7.42 (1.22)
TNFα [median (range), pg/g of tissue]
0	10.62 (2.07)	-	7.58 (1.75)c	6.40 (1.52)	8.11 (1.31)c	5.98 (1.45)
LPS	28.25 (3.35)	-	45.33 (13.06)c	21.44 (8.12)	19.07 (4.72)c	17.87 (2.11)
Gastric juice	18.02 (5.97)	-	10.76 (2.08)c	8.51 (2.05)	10.17 (3.23)c	9.13 (1.61)

Patients were divided as either H pylori-positive or H pylori-negative. LPS: Endotoxin of Escherichia coli O144:H4.

^aP < 0.05,

^bP < 0.01, vs H pylori negative patients.

^cP vs H pylori negative patients. non-significant.