Importance of MutL homologue MLH1 and MutS homologue MSH2 expression in Turkish patients with sporadic colorectal cancer

Table 1 Clinicopathological parameters and MLH1 and MSH2 expressions n (%)

	MLH1 (+)	MLH1 (-)	P	MSH2 (+)	MSH2 (-)	P
Gender			0.943			0.049
Male	26 (57.8)	17 (58.6)		38 (55.1)	0 (0)
Female	19 (42.2)	12 (4.4)		31 (44.9)	5 (100)
Age (yr)			0.602			0.579
< 50	15 (33.3)	8 (27.6)		22 (31.9)	1 (20)
≥ 50	30 (66.7)	21 (72.4)		47 (68.1)	4 (80)
Localization			0.630			0.244
Right colon	10 (22.2)	9 (31)		16 (23.2)	3 (60)
Left colon	11 (24.4)	9 (31)		20 (29)	0 (0)
Rectum	16 (35.6)	7 (24.1)		22 (31.9)	1 (20)
Colon (NOS)	8 (17.8)	4 (13.8)		11 (15.9)	1 (20)
Tumor size			0.757			0.969
< 5 cm	17 (37.8)	12 (41.4)		27 (39.1)	2 (40)
> 5 cm	28 (62.2)	17 (58.6)		42 (60.9)	3 (60)
Macroscopic type			0.479			0.144
Ulcerofungating	22 (48.8)	17 (57.1)		36 (52.1)	3 (60)
Ulceroinfiltrative	22 (48.8)	12 (42.9)		33 (47.9)	1 (20)
Polypoid	1 (2.4)	0 (0)		0 (0)	1 (20)
Tumor type			0.206			0.219
Adenocarcinoma	35 (77.7)	27 (85.1)		58 (84)	4 (80)
Mucinous AdenoCarcinoma	8 (17.9)	2 (14.9)		10 (14)	0 (0)
Adeno+neuroendocrine	1 (2.2)	0 (0)		0 (0)	1 (20)
Undifferentiated carcinoma	1 (2.2)	0 (0)		1 (2)	0 (0)
Grade			0.805			0.743
1	4 (10.5)	4 (14.8)		7 (11.7)	1 (20)
2	32 (84.2)	21 (77.8)		49 (81.7)	4 (80)
3	2 (5.3)	2 (7.4)		4 (6.7)	0 (0)
Tumor necrosis			0.451			0.660
-	5 (11.1)	5 (17.2)		9 (13)	1 (20)
+	40 (88.9)	24 (82.8)		60 (87)	4 (80)
Stromal desmoplasia			0.258			0.556
Mild	12 (26.7)	5 (17.2)		15 (21.7)	2 (40)
Moderate	28 (62.2)	23 (79.3)		48 (69.6)	3 (60)
Severe	5 (11.1)	1 (3.4)		6 (8.7)	0 (0)
Stromal inflammatory reaction			0.512			0.352
Mild	9 (20)	9 (31)		18 (26.1)	0 (80)
Moderate	31 (68.9)	18 (62.1)		45 (65.2)	4 (80)
Intense	5 (11.1)	2 (6.9)		6 (8.7)	1 (20)

MLH: MutL homologue; MSH: MutS homologue; NOS: Not otherwise specified.