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©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 7, 2007; 13(33): 4437-4444
Published online Sep 7, 2007. doi: 10.3748/wjg.v13.i33.4437
Published online Sep 7, 2007. doi: 10.3748/wjg.v13.i33.4437
Table 1 Clinicopathological parameters and MLH1 and MSH2 expressions n (%)
MLH1 (+) | MLH1 (-) | P | MSH2 (+) | MSH2 (-) | P | |
Gender | 0.943 | 0.049 | ||||
Male | 26 (57.8) | 17 (58.6) | 38 (55.1) | 0 (0) | ||
Female | 19 (42.2) | 12 (4.4) | 31 (44.9) | 5 (100) | ||
Age (yr) | 0.602 | 0.579 | ||||
< 50 | 15 (33.3) | 8 (27.6) | 22 (31.9) | 1 (20) | ||
≥ 50 | 30 (66.7) | 21 (72.4) | 47 (68.1) | 4 (80) | ||
Localization | 0.630 | 0.244 | ||||
Right colon | 10 (22.2) | 9 (31) | 16 (23.2) | 3 (60) | ||
Left colon | 11 (24.4) | 9 (31) | 20 (29) | 0 (0) | ||
Rectum | 16 (35.6) | 7 (24.1) | 22 (31.9) | 1 (20) | ||
Colon (NOS) | 8 (17.8) | 4 (13.8) | 11 (15.9) | 1 (20) | ||
Tumor size | 0.757 | 0.969 | ||||
< 5 cm | 17 (37.8) | 12 (41.4) | 27 (39.1) | 2 (40) | ||
> 5 cm | 28 (62.2) | 17 (58.6) | 42 (60.9) | 3 (60) | ||
Macroscopic type | 0.479 | 0.144 | ||||
Ulcerofungating | 22 (48.8) | 17 (57.1) | 36 (52.1) | 3 (60) | ||
Ulceroinfiltrative | 22 (48.8) | 12 (42.9) | 33 (47.9) | 1 (20) | ||
Polypoid | 1 (2.4) | 0 (0) | 0 (0) | 1 (20) | ||
Tumor type | 0.206 | 0.219 | ||||
Adenocarcinoma | 35 (77.7) | 27 (85.1) | 58 (84) | 4 (80) | ||
Mucinous AdenoCarcinoma | 8 (17.9) | 2 (14.9) | 10 (14) | 0 (0) | ||
Adeno+neuroendocrine | 1 (2.2) | 0 (0) | 0 (0) | 1 (20) | ||
Undifferentiated carcinoma | 1 (2.2) | 0 (0) | 1 (2) | 0 (0) | ||
Grade | 0.805 | 0.743 | ||||
1 | 4 (10.5) | 4 (14.8) | 7 (11.7) | 1 (20) | ||
2 | 32 (84.2) | 21 (77.8) | 49 (81.7) | 4 (80) | ||
3 | 2 (5.3) | 2 (7.4) | 4 (6.7) | 0 (0) | ||
Tumor necrosis | 0.451 | 0.660 | ||||
- | 5 (11.1) | 5 (17.2) | 9 (13) | 1 (20) | ||
+ | 40 (88.9) | 24 (82.8) | 60 (87) | 4 (80) | ||
Stromal desmoplasia | 0.258 | 0.556 | ||||
Mild | 12 (26.7) | 5 (17.2) | 15 (21.7) | 2 (40) | ||
Moderate | 28 (62.2) | 23 (79.3) | 48 (69.6) | 3 (60) | ||
Severe | 5 (11.1) | 1 (3.4) | 6 (8.7) | 0 (0) | ||
Stromal inflammatory reaction | 0.512 | 0.352 | ||||
Mild | 9 (20) | 9 (31) | 18 (26.1) | 0 (80) | ||
Moderate | 31 (68.9) | 18 (62.1) | 45 (65.2) | 4 (80) | ||
Intense | 5 (11.1) | 2 (6.9) | 6 (8.7) | 1 (20) |
- Citation: Erdamar S, Ucaryilmaz E, Demir G, Karahasanoglu T, Dogusoy G, Dirican A, Goksel S. Importance of MutL homologue MLH1 and MutS homologue MSH2 expression in Turkish patients with sporadic colorectal cancer. World J Gastroenterol 2007; 13(33): 4437-4444
- URL: https://www.wjgnet.com/1007-9327/full/v13/i33/4437.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i33.4437