Lithocholic acid induction of the FGF19 promoter in intestinal cells is mediated by PXR

Figure 2 CYP3A4 and FGF19 promoter constructs and sequence alignment of the human and murine FGF19/Fgf15 regulatory regions. A: CYP3A4 and FGF19 promoter constructs used for transient transfection assays. The positions are calculated relative to the major transcription start site; B: Sequence comparison of homologous regions in the human FGF19 and murine Fgf15 promoters. The locations of the DR3 and ER6 elements identified in the human FGF19 promoter by NUBIScan analysis are indictated by bold letters.